Premier Internal MedicinePremier Internal MedicineAlexandra Zelenka, MD

Hormone Therapy & Pellet Therapy in Tampa

There is more than one way to take a hormone, and the right one depends on the hormone, your labs, your schedule, and what you are willing to do every day. At Premier Internal Medicine, Dr. Alexandra Zelenka walks through pellets, injections, creams and gels, and oral preparations with you, then builds a plan around the method you will actually stay with.

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What Bio-Identical Hormone Therapy Is

Bio-identical hormone therapy uses hormones that are structurally identical to the ones the human body makes, such as estradiol, progesterone, and testosterone. The word bio-identical describes the molecule, not the delivery method and not the manufacturer. It does not by itself mean a preparation is safer, stronger, or more natural than another, and it is not a substitute for the lab work and follow-up that make hormone therapy reasonable to take. Some bio-identical products are commercially manufactured and others are prepared by a compounding pharmacy. We will tell you which category your prescription falls into, and what that difference means, before you start.

This page is about the practical side of that therapy: the delivery method. The same hormone can be implanted as a pellet under the skin, injected, applied as a cream or gel, or taken by mouth, and each route behaves differently in the body and asks something different of you week to week. Pellets ask you to come in for a brief procedure a few times a year and then largely forget about it. Injections and creams put the dose in your hands and are easier to adjust or to stop. Neither is universally better. Choosing between them is a real clinical decision, and it is one we make with you rather than for you.

Our broader clinical overview of hormone evaluation, symptoms, and testing lives on the Hormone Optimization & Replacement page. Read that one if you are still deciding whether hormone therapy is worth investigating at all. Read this one if you have decided to look into it and want to know what the treatment actually looks like day to day, including what a pellet insertion involves and how often it has to be repeated.

Men and Women Who Commonly Ask About Delivery Methods

  • Women in perimenopause or menopause weighing patches, creams, and pellets against each other
  • Men considering testosterone therapy who would rather not keep up a weekly injection routine
  • Patients who have tried a daily cream and found it inconvenient, messy, or easy to forget
  • Patients concerned about transferring topical hormone to a partner, child, or pet through skin contact
  • Patients whose symptoms return late in the week on an injection schedule
  • Anyone who travels often and struggles to keep a daily or weekly regimen going
  • Patients already on hormone therapy elsewhere who want their dosing and monitoring reviewed
  • Patients who simply want the options explained plainly before committing to anything

What to Expect

  • Bio-identical hormone therapy for both men and women, with the delivery method chosen individually rather than by default
  • In-office pellet insertion: a brief procedure performed under local anesthetic, with no general anesthesia and no stitches
  • Injections, topical creams and gels, and oral preparations offered alongside pellets, so the method can be matched to the hormone and to your life
  • Baseline and follow-up laboratory testing, with dosing adjusted from your labs and your symptoms together rather than from a fixed protocol
  • Pellets are generally re-dosed every few months, with the interval set individually and confirmed by testing rather than by the calendar alone
  • Self-pay pricing stated up front: $200 for the initial consultation and $100 for each follow-up or phone visit
  • Open to new self-pay consultative patients even though the insurance-based primary care panel is currently full

How We Choose and Manage a Delivery Method

The method matters as much as the molecule. Our process is built to get that choice right at the start and to keep checking it afterward.

Evaluation and Baseline Labs

We start with your symptoms, your medical and family history, the medications and supplements you already take, and a physical exam. Baseline laboratory testing is drawn before any hormone is prescribed, so that later results have something to be compared against. What we test depends on which hormones are in question and on your sex, age, and history.

Choosing the Route Together

Once we know which hormones are involved, we compare the honest trade-offs of each route: how often you have to do something, how quickly a dose can be changed or stopped, whether the hormone can be given that way at all, and what each option costs. Some hormones suit a pellet well and others do not. A method you will not keep up with is not the right method, however good it looks on paper.

The Procedure or the Prescription

If pellets are the plan, the insertion is done here in the office and takes only a short time. If injections, creams, or oral medication are the plan, we send the prescription and teach the technique in the room, including where and how to apply a topical and how to lower the risk of transferring it to someone else through skin contact.

Monitoring and Adjusting

Hormone therapy is not a one-time prescription. We repeat labs after you start, review how you actually feel, and adjust the dose, the interval, or the route itself if the first choice is not working. Monitoring continues for as long as you are on therapy, and follow-up visits can often be handled by phone when a physical exam is not needed.

Delivery Methods, Side by Side

There is no single best route for everyone. Each of these has a real advantage and a real drawback, and the drawback is usually what decides it. Candidates are evaluated individually, and not every hormone can be given by every route.

Pellets

Small pellets are placed under the skin in a brief in-office procedure and are designed to release hormone steadily over the following months. The appeal is that there is nothing to remember daily or weekly. The trade-off is that once a pellet is in, the dose cannot be dialed back the way an injection or a cream can, so we tend to start conservatively. Pellets are generally re-dosed every few months, often somewhere in a three to six month range, with your own interval set from your labs and symptoms rather than from a fixed schedule.

Injections

Intramuscular or subcutaneous injections are given on a repeating schedule, most often at home after we teach the technique. Dosing is flexible and easy to change, and therapy can be stopped quickly if that becomes necessary. The trade-offs are the injection itself and the fact that some patients notice symptoms drifting back toward the end of an interval, which is usually a reason to adjust the frequency rather than to abandon the route.

Creams and Gels

Topical hormone is applied to the skin daily. It is needle-free, simple to adjust or stop, and absorption can be checked with labs. The trade-offs are that it has to be done every day without fail, that absorption varies from person to person, and that the medication can transfer to another person or a pet through skin contact. We review application sites, timing, and covering the treated area, which lowers that risk without eliminating it.

Oral Preparations

Some hormones are routinely and appropriately given by mouth, such as micronized progesterone for women who need endometrial protection alongside estrogen. Oral dosing is the easiest thing to take and the easiest to stop. Because medication taken by mouth passes through the liver before reaching the rest of the body, this route is not the right choice for every hormone, and we will say so plainly when it is not.

Benefits

A Method Matched to Your Life

The best-designed regimen fails if it does not fit your week. Choosing among pellets, injections, creams, and oral options makes it more likely you stay on therapy long enough to know whether it helps.

Fewer Things to Remember

For patients who choose pellets, there is no daily cream and no weekly injection to keep up with between visits. For some patients, removing that daily step is what makes staying on therapy realistic.

Steadier Day-to-Day Dosing

Pellets and daily topicals are designed to deliver hormone continuously rather than in a peak-and-trough pattern. Some patients on longer injection intervals prefer this, though response differs from person to person.

Dosing Guided by Your Own Labs

Doses and intervals are set from your baseline and follow-up testing alongside your symptoms, not from a standard package. If the numbers and the way you feel disagree, we look into why.

One Physician Following the Whole Picture

Dr. Alexandra Zelenka is an internal medicine physician and a member of the American College of Physicians and of the Institute of Functional Medicine. Hormone therapy is reviewed in the context of your other conditions, medications, and lab work rather than in isolation.

Clear Self-Pay Pricing

These services are self-pay and are not billed to insurance. The initial consultation is $200 and follow-up or phone visits are $100, so you know what a visit costs before you book it.

What the Process Looks Like

Visit One: Consultation and Baseline Labs

We review your symptoms, history, medications, and goals, perform an examination, and order baseline laboratory testing. Nothing is prescribed before those results are back. This visit is $200, self-pay. If you already have recent outside labs, bring them and we will use whatever is still current.

Visit Two: Results and Choosing a Route

We go through your results together, discuss whether hormone therapy is appropriate for you at all, and compare the delivery methods against your schedule, your preferences, and the specific hormones involved. If therapy is not a good idea in your case, we will tell you that and explain why. This visit is $100, self-pay.

Insertion Day, If You Choose Pellets

The insertion is a brief in-office procedure. The skin over the upper hip or gluteal area is cleaned and numbed with a local anesthetic, a very small incision is made, the pellet or pellets are placed under the skin, and the incision is closed with adhesive strips rather than stitches. You are awake the whole time and go home the same day.

The First Few Days After

You will be given written aftercare instructions. These generally include keeping the site clean and dry, avoiding swimming, baths, and hot tubs for several days, and holding off on heavy lower-body exercise for a few days. Bruising, tenderness, or mild swelling at the site is common and usually settles on its own. Call the office for spreading redness, drainage, fever, or pain that is getting worse rather than better.

Follow-Up Testing

We repeat labs once you have been on therapy long enough for the results to mean something, and pair them with a conversation about how you actually feel. Doses, intervals, and sometimes the route itself are adjusted at this point. Follow-up visits are $100, and many of them can be done by phone.

Ongoing Re-Dosing and Monitoring

Pellets are re-dosed periodically, generally every few months, with your own interval individualized from your labs and your symptoms. Patients on injections, creams, or oral therapy continue on their prescribed schedule with periodic monitoring. Either way, therapy is reviewed on an ongoing basis rather than left to run indefinitely.

Safety, Monitoring, and Who Should Not Start

Hormone therapy is a prescription treatment with real risks as well as real benefits, and it is not appropriate for everyone. A history of hormone-sensitive cancer, blood clots, certain cardiovascular or liver conditions, unexplained vaginal bleeding, and current or planned pregnancy are among the reasons hormone therapy may be unsafe or may need to be approached differently. Candidates are evaluated individually. Part of what you are paying for at the first visit is an honest answer about whether you should be doing this at all.

Monitoring is not optional. Which tests we repeat, and how often, depends on the hormone and on you. For men on testosterone, monitoring commonly includes red blood cell measures, because testosterone can raise them, along with prostate-related and estradiol testing where clinically appropriate. For women who take estrogen and still have a uterus, progesterone is prescribed alongside it to protect the uterine lining. We also watch for the ordinary side effects of each route, including acne, fluid retention, mood or sleep changes, hair changes, and reactions at the application or insertion site.

Pellet insertion is a minor procedure, and like any procedure it carries risks. These include bruising, soreness, bleeding, infection at the site, a small scar, and the possibility that a pellet works its way back out through the incision, which is called extrusion. One practical limitation deserves emphasis: once a pellet is placed, the dose cannot easily be reduced. If a pellet dose turns out to be higher than you need, the usual course is to manage symptoms and adjust at the next insertion, which is a strong argument for starting conservatively. Anyone who would prefer a route they can stop the same day is usually better served by an injection, a cream, or an oral option.

No hormone therapy cures aging, and no one can promise you a particular result. Many patients report improvement in the symptoms that brought them in, some notice little difference, and some decide the trade-offs are not worth it and stop. We would rather set that expectation before you spend money than afterward.

Pricing, Insurance, and Booking

Hormone therapy, pellet therapy, and our other consultative services are self-pay and are not billed to insurance. The initial consultation is $200 and follow-up or phone visits are $100. Laboratory testing, medication, and the pellets themselves are billed separately from the visit fee, and we will go over those costs with you before anything is ordered.

Our insurance-based primary care panel is currently full, and new primary care patients are accepted only by special request. The self-pay consultative track, which includes hormone therapy and pellet therapy, is open to new patients. You do not need to be an established primary care patient here to be seen for hormone therapy.

Premier Internal Medicine is at 13015 W Linebaugh Ave, Suite 101, Tampa, FL 33626, in the Westchase area of Tampa Bay. The office is open Monday through Friday, 10am to 5pm. Call (813) 814-4204, fax (813) 814-4219, or email premier@zelenkamd.com to schedule.

Common Questions About Hormone Therapy & Pellet Therapy

What does bio-identical actually mean?

It means the hormone molecule is structurally identical to the one your body produces, such as estradiol, progesterone, or testosterone. It is a statement about the molecule and nothing else. It does not tell you who manufactured the product, how it is delivered, or whether it is right for you, and it does not by itself make a preparation safer or more effective than another. Some bio-identical hormones are commercially manufactured and others are prepared by a compounding pharmacy. We will tell you which yours is, and discuss what that difference means, before you start.

What is the pellet insertion actually like?

It is a brief in-office procedure, not surgery in an operating room. You lie on your side, the skin over the upper hip or gluteal area is cleaned and numbed with a local anesthetic, and a very small incision is made. The pellet or pellets are placed under the skin, and the incision is closed with adhesive strips rather than stitches. You are awake the entire time and can drive yourself home afterward.

How often do pellets need to be replaced?

Pellets are generally re-dosed every few months rather than on a fixed date, and in practice the interval often falls somewhere in a three to six month range. Your own interval is individualized. It depends on the hormone, the dose, your metabolism, and, most importantly, on what your follow-up labs and your symptoms show. Some people need re-dosing sooner than a typical interval and some later, and we would rather test than guess.

What can I not do after an insertion?

You will get written aftercare instructions at the visit. In general we ask you to keep the site clean and dry, to avoid swimming, baths, and hot tubs for several days so the incision is not soaked, and to hold off on heavy lower-body exercise for a few days. Bruising, tenderness, or mild swelling at the site is common and usually resolves on its own. Call the office if you develop spreading redness, drainage, fever, or pain that is worsening rather than improving.

Are pellets better than injections or creams?

Not inherently, and anyone who tells you one route is simply better is skipping the part that matters. Pellets remove the daily and weekly steps, which is exactly what some patients need in order to stay on therapy. Injections and creams keep the dose in your hands, which makes them easier to adjust and easier to stop, and that flexibility matters more for other patients. Some hormones are also better suited to one route than another. The comparison is worth having in person, with your labs and your schedule on the table.

Can a pellet be taken out if I do not tolerate it?

A pellet can sometimes be removed, but removal is not simple and is not the routine answer to a dose that turns out to be higher than you need, because pellets sit under the skin and begin dissolving. This is the main practical limitation of the route, and it is why we tend to start at a conservative dose and adjust at the next insertion instead. If being able to stop treatment the same day is important to you, an injection, cream, or oral preparation is the better fit, and we will say so.

Is any of this covered by insurance, and what does it cost?

Hormone therapy and pellet therapy at Premier Internal Medicine are self-pay and are not billed to insurance. The initial consultation is $200, and follow-up or phone visits are $100. Laboratory testing, medication, and the pellets themselves are separate from the visit fee and are quoted before anything is ordered. Our insurance-based primary care panel is currently full, but the self-pay consultative track is open to new patients, so you do not need to be an established primary care patient here to be seen for this.

Talk Through the Options Before You Commit

A consultation is a conversation about whether hormone therapy makes sense for you and, if it does, which delivery method fits your life. Self-pay: $200 for the initial visit, $100 for follow-ups. Call (813) 814-4204 or book online.

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